Braak Staging over Time: A Possible Cohort Effect  

 
   Lead Investigator:    Peter T. Nelson
   Institution      :    University of Kentucky
   E-Mail           :    pnels2@email.uky.edu
   Proposal ID      :    59


   Publications:


1  Abner EL, Kryscio JR, Schmitt FA, Frederick A, Santacruz KA, Jicha GA, Lin Y, Neltner JM, Smith CD, Charles D, Van Eldik LJ, Linda J, Nelson PT
   "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease-fact or fiction
   Journal Article  J Alzheimers Dis,25:445-453,2011,PMC3171001

   PUBLISHED



2  Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Santacruz K, Smith CD, Patel E, Markesbery WR
   Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease
   Journal Article  J Neuropathol Exp Neurol,68:774-784,2009,PMC2725359

   PUBLISHED





   Proposal Description:
   1. Correlate date (year) of birth with changes in Braak/Cerad scoring  2. Evaluate hypothesis that cohort effect in Braak and Cerad    The goal of this project is to perform epidemiologic research to provide circumstantial, but statistically robust, evidence about the role(s) of environmental factors (referent to year of birth) on the development of AD???type pathology.